Matching Algorithm

Alliance for Paired Kidney Donation's Algorithm for Transplant Pairing

In the U.S., more than 100,000 people are waiting for a kidney transplant, but only 17,000 of them will receive a kidney this year. Of those, only 6,000 come from living donors. For the kidney patients who are fortunate enough to have a friend or family member step forward to donate, most are incompatible.

For patients and their families, the odds are overwhelming. The Alliance for Paired Kidney Donation is rewriting that story.

By including those incompatible pairs in the paired donation registry, the APKD is seeing more than a 50% rise in matches. That means 50% more patients who are finding the gift of life. With more pairs in the system, the rise in matches will continue to climb, and that’s exactly what the APKD is working toward.

How does it work?

The APKD uses a Nobel prize winning algorithm to match one incompatible pair with another. A scoring rubric, developed by a team of healthcare professionals, is used help find the best possible match.

Scoring Rubric

The scoring rubric was adopted by the Scientific Operations Committee on February 6, 2014.

The APKD software awards points according to the following criteria:

DR-locus mismatches 0 mismatches 2.0
1 mismatch 1.0
Any other mismatches 0.0
Zero-antigen mismatch Yes 6.0
No 0.0
High PRA >=80 10.0
>=50 6.0
Any other PRA 0.0
Travel distance Same center or same city 3.0
Any other distance 0.0
Pediatric recipient Age <=5 4.0
Age <= 17 2.0
Any other age 0.0
Recipient once was donor Yes 6.0
No 0.0
Known negative cross match and PRA >=80 Yes 6.0
No 0.0